The cell puddle family consists of creatures that typically resemble organic cells and have at least one nucleus.
- Main article: Chemical Goolix
The Chemical Goolix, also known as the Acid Goolix, is a acidic species who's body is encased in a green substance. This caustic overcoat makes it highly deadly towards most other Pikmin species, with the exception of the Green Pikmin who're immune to the acidic overcoat.
- Main article: Doom Goolix
The Doom Goolix is an unspecified Goolix species that has been infected by the doom essence and infused it into its DNA. Its purple exterior makes it highly poisonous, meaning that only the White Pikmin species can harm it, and even then they are at risk of contacting the Doom essence and becoming Doom Pikmin.
- Main article: Electro Goolix
The Electro Goolix is a Cell Puddle that has developed and evolved electromagnetic properties, potentially making it the most dangerous type of Goolix to Pikmin species. It can instantly kill most Pikmin species with the exception of the Yellow Pikmin, yet they can still drown within the goo-like substance.
- Main article: Frozen Goolix
The Frozen Goolix is a idle form of the Goolix encased in ice. Unlike other Goolix species, it is incapable of moving, and as such leaves it vulnurable to Cyan Pikmin
- Main article: Ghoulix
The Ghoulix is, presumably, an undead Goolix that can only be harmed by Tech Pikmin. Little research is known of this specimen however.
- Main article: Glooplix
The Glooplix is a highly rare subspecies of multi-elemental Goolix found above ground. It can use acid, electric, fire, toxic, and water-based slime to protect itself against Pikmin.
- Main article: Goolarva
Goolarva is a "half-Goolix" - a smaller variant of Goolix with only one nuclei as opposed to the standard two.
- Main article: Goolix
The Goolix is a aquatic-based enemy. Its entire body is encased in a goo-like substance, with two nuclei within its mass. It moves slowly around the area, drowning most other Pikmin that make contact with it, with the exception of Blue Pikmin. As such, Blue Pikmin are the only Pikmin type that can damage it safely. Any other Pikmin caught in its mass can be thrown out by Blue Pikmin as well.
King Rainbow Goolix
- Main article: King Rainbow Goolix
The King Rainbow Goolix is a larger, and more durable variant to the Rainbow Goolix.
- Main article: Lava Goolix
The Lava Goolix is a mutated species that has infused Fiery Bulblax DNA into itself. Because of this, they will attack any enemy except for the Bulblax in question, and capable of spurting highly flammable puddles, making Red Pikmin the only type to be able to withstand the heat. Intriguingly, it can also fuse with more members of itself.
- Main article: Lord Goolix
The Lord Goolix is a colossal-sized Goolix species with fire and electric-based properties. It is capable of shooting projectiles at enemies in a manor similar to the Man-at-Legs.
- Main article: Magmix
The Magmix is an armored Lava Goolix, with its body encased in not only molten lava, but also cracked rocky armory. This armor must be chipped away first before Red Pikmin can damage it.
- Main article: Mega Goolix
The Mega Goolix is a humongous blue liquid blob containing a large yellowish-whitish orb and a slightly smaller blue-green marble-like orb.
- Main article: Molten Goolix
The Molten Goolix is a lava-based Goolix species, with a crimson-colored body and a set of molten orbs. This type is capable of splitting its body away from the nuclei and continue its attack on threats close to it. The only Pikmin capable of fighting it is the Crimson Pikmin.
- Main article: Rainbow Goolix
The Rainbow Goolix is a color-shifting Goolix species that changes its very element depending on its coloration. Different Pikmin types are required depending on the different element it changes into.
Rainbow Ranged Goolix
- Main article: Rainbow Ranged Goolix
- Main article: ranged Goolix
The Ranged Goolix resembles a pink Goolix and can shoot watery projectiles. Only Blue Pikmin are immune to its attacks. Purple Pikmin can be used to take large portions of its health, but they will drown eventually if not whistled to.
- Main article: Shadow Goolix
- Main article: Sludge Goolix
The Sludge Goolix is a large black-colored Goolix. The nucleus inside it will alter colors, and depending on the color the pikmin type will be the only option to damage it.
- Main article: Sticky Goolix
The Sticky Goolix is an adhesive species of Goolix that occasionally releases the adhesive onto Pikmin, which will immobilize and absorb them. The only Pikmin type immune to it is the Black Pikmin.
- Main article: Toxic Goolix
The 'Toxic Goolix is a species of Goolix with a poisonous purple membrane. It also emits poison gas that will poison all but White Pikmin. The only way to harm this beast is by having White Pikmin attack its nuclei.
- Main article: Vapor Goolix
The Vapor Goolix, also known as the Steam Goolix, is a Goolix that is composed of gases rather than liquids. Technically it doesn't have a means to harm Pikmin, but is still capable of flight and able to knock Pikmin back by bashing its nuclei together.